Aroxia 60mg, 90mg, 120mg Tablet

Etoricoxib 60mg, 90mg, 120mg Tablet

COMPOSITION

Aroxia 60 Tablet: Each tablet contains Etoricoxib INN 60 mg.

Aroxia 90 Tablet: Each tablet contains Etoricoxib INN 90 mg.

Aroxia 120 Tablet: Each tablet contains Etoricoxib INN 120 mg.

PHARMACOLOGY

Aroxia is the preparation of Etoricoxib. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function

INDICATION

Aroxia (Etoricoxib) is indicated for relief of pain and inflammation in:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Other chronic musculoskeletal disorders
  • Acute gout
  • Dysmenorrhoea &
  • Following dental surgery

DOSAGE AND ADMINISTRATION

Adult and adolescent over 16 years:

  • Osteoarthritis, chronic musculoskeletal disorders & dysmenorrhoea: 60 mg once daily
  • Rheumatoid arthritis: 90 mg once daily
  • Pain following dental surgery & acute gout: 120 mg once daily

CONTRAINDICATION

Aroxia (Etoricoxib) is contraindicated to patients with known hypersensitivity to Aroxia (Etoricoxib), patients with active peptic ulceration or gastro-intestinal (GI)  bleeding, patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of  acetylsalicylic acid or other Non-Steroidal Anti-inflammatory Drugs (NSAIDs), patient having inflammatory bowel disease, severe congestive heart failure, to children and adolescents under 16 years of age.

In patients with advanced renal disease, treatment with Aroxia (Etoricoxib) is not recommended. Clinical experience in patients with estimated creatinine clearance of <30 ml/min is very limited. If therapy with Aroxia (Etoricoxib) must be initiated in such patients, close monitoring of the patient’s renal function is advisable.

PRECAUTION

Caution should be taken when initiating treatment with Aroxia (Etoricoxib) in patients with considerable dehydration. It is advisable to rehydrate patients prior to starting therapy with Aroxia (Etoricoxib). The possibility of fluid retention, oedema of hypertension should be taken into consideration when Aroxia (Etoricoxib) is used in patients with pre-existing oedema, hypertension, or heart failure. Independent of treatment, patients with a prior history of GI perforation, ulcers and bleeding (PUB) and patients greater than 65 years of age are  known to be at a higher risk for a PUB.

SIDE EFFECTS

Dry mouth taste disturbance, mouth ulcers, flatulence, constipation, appetite and weight change, chest pain, fatigue, paraesthesia, influenza-like syndrome & myalgia. 

DRUG INTERACTION

Oral anticoagulants, diuretics and ACE inhibitors, Acetylsalicylic acid, Cyclosporin and Tacrolimus, Lithium, Methotrexate, oral contraceptives, Ketoconazole, Rifampicin and Antacids have interaction with  Aroxia (Etoricoxib).

USE IN PREGNANCY AND LACTATION

As with other drugs known to inhibit prostaglandin synthesis, use of Aroxia (Etoricoxib) should be avoided in late pregnancy because it may cause premature closure of the ductus arteriosus. Aroxia (Etoricoxib) should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the foetus. Aroxia (Etoricoxib) is not known whether this drug is excreted in human milk.

STORAGE

Store at a cool & dry place, protect from light & moisture. Keep out of the reach of children.

PACKING

Aroxia 60 Tablet: Box containing 10 x 3 tablets in blister pack.

Aroxia 90 Tablet: Box containing 10 x 2 tablets in blister pack.

Aroxia 120 Tablet: Box containing 10 x 2 tablets in blister pack.

Aroxia 60mg, 90mg, 120mg Tablet
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