This is a combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.
Each tablet contains Paracetamol BP 500 mg & Caffeine BP 65 mg.
- Period pain
- Sore throat
- Help to reduce the temperature
- Aches and pain of colds and flu
DOSAGE & ADMINISTRATION
Adults: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.
Not recommended for children below 12 years.
Hypersensitivity to Paracetamol, Caffeine or any other components of it.
This combination may cause skin rashes, neutropenia & gastro-intestinal disturbances etc. High dose administration may cause hepatotoxicity.
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.
PREGNANCY & LACTATION
Although there is epidemiological evidence of the safety of Paracetamol in pregnancy & lactation, medical advice should be sought before using this product.
WARNING & PRECAUTION
Paracetamol & Caffeine should be given cautiously in the following cases: In patients with hepatic or renal failure, in patients taking other hepatotoxic medication. Prolonged use of the drug without consulting a physician should be avoided.
Symptoms of Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 40 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur.
Store in a cool and dry place, protect from light and moisture. Keep all medicines out of the reach of the children.
Box containing 10 x 10 tablets in blister pack.