Each Tablet Contain Folic Acid 5 mg BP.
Folic acid as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cell by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids methylate RNA and generate and use format. Using vitamin B12 as a cofactor. folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
Folic acid is indicated for the treatment of-
* Folic acid deficiency.
* Megaloblastic anemia.
* Anemias of nutritional origins, pregnancy infancy, or childhood.
Dosage & Administration
* Initially 5 mg daily for 4 months.
* maintenance: 5 mg every 1-7 days depending on the underlying disease.
* Up to 1 year 500 mcg/kg daily.
* Over 1 year: Same as adult dose.
Folic acid is contraindicated in patients who have shown previous intolerance to the drug.
Folic acid is generally well tolerated, Gastro-intestinal disturbances may occur Hypersensitivity reactions have been reported rarely.
Precautions & Warnings
It should be used with caution in patients who may have folate dependent tumours it should never be given alone or in conjunction with inadequate amounts of vitamin B12 for the treatment undiagnosed megaloblastic anaemia Although four acid may produce a haematopoietic response in patients with a megaloblastic anaemia due to vitamin B12 deficiency it should not be given sons in vitamin B12 deficiency status as it may precipitate the onset of subacute combined degeneration of the cord in elderly people a cobalamin absorption test should be done before long term folate. No harmful results found from short courses of folate.
Pregnancy & Lactation
No special precautions and known.
None has been reported.
Store in a cool & dry place below 30°C. Keep away from light and moisture. Keep all medicines out of the reach of children
Each box contains 10 X 10’s tablets in blister pack.