Loderm Cream

Loderm Cream
Clotrimazole BP 10 mg.

Each gram Cream Contains Clotrimazole BP 10 mg.

Clotrimazole is a broad-spectrum antifungal agent used to treat dermal infections caused by various species of pathogenic dermatophytes, Yeasts, moulds and bacteroids. Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane. Because ergosterol directly promotes the growth of fungal cells in a hormone-like fashion, the rapid onset of the above events leads to dose-dependent inhibition of fungal growth.

Loderm is indicated for
* All dermatomycoses due to dermatophytes (Trichophyton species) e.g. athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis)
* All dermatomycoses due to yeast (Candida species) e.g. candida vulvitis, candida balanitis
* Dermatomycoses due to moulds and other fungi
* Skin diseases showing secondary infection with these fungi  

Some examples of skin infections included in the above points are interdigital mycosis (e.g. athlete’s foot), paronychias (associated with nail mycoses), mycoses in skin folds, candida vulvitis, Candida balanitis, Pityriasis Versicolor, erythrasma.

Dosage & Administration
Loderm Cream: This should be thinly applied 2-3 times daily to the infected sites and rubbed in. On account of excellent efficacy, a small amount of cream is usually sufficient for an area about the size of the palm. For the treatment to become a complete success, reliable and sufficiently long-time application of Clotrimazole Cream is important. The duration of treatment varies; It depends among other factors on the extent and localization of the disease.

Recommended duration of treatment-
* Dermatomycoses: 3-4 weeks.
* Candida Vulvitis and Candida balanitis: 1-2 weeks
* Erythrasma and pityriasis Versicolor: 3 weeks (approximately).

In fungal infection of the feet and to prevent relapse, treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease. After washing, the feet should be thoroughly dried (particularly the spaces between the toes).

Clotrimazole Cream is odorless, can be washed off, and does not stain clothing

Hypersensitivity to Clotrimazole

Warnings & Precautions
Avoid contact with eyes upon topical application. Child <3 Yrs. Pregnancy, Lactation. If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy.

Side Effect
When applied topically, Clotrimazole is well tolerated with an external application, systemic effects are not observed. Local irritation or burning sensation may occur in very few cases but these symptoms are not considered harmful.

Pregnancy & Lactation
Pregnancy Category- Not Classified FDA has not yet classified the drug into a specified pregnancy category.

Small amounts of imidazoles may be absorbed systemically following topical and vaginal administration.

Excretion in milk unknown; use with caution.

Drug Interaction
No significant drug interactions have been reported.

In case of accidental oral ingestion, supportive measures should be taken.

Store in a cool & dry place below 30°C. Keep away from light and moisture. Keep all medicines out of the reach of children.

Each tube contains 10 gm of Clotrimazole Cream

Loderm Cream
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