Composition
Adrox CV (500 mg + 125 mg) Tablet: Each film coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 500 mg and diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 125 mg.
Pharmacology
Cefuroxime is one of the bactericidal second generation cephalosporin antibiotics, which is active against a wide range of gram-positive and gram-negative susceptible organisms including many beta-lactamase producing strains. It is indicated for the treatment of infections caused by sensitive bacteria.
Clavulanic Acid has a similar structure to the beta-lactam antibiotics but binds irreversibly to the beta-lactamase enzymes.
The presence of Clavulanic Acid in Adrox CV formulations protects Cefuroxime from degradation by beta-lactamase enzymes and effectively extends the antibacterial spectrum of Cefuroxime to include many bacteria normally resistant to Cefuroxime and other cephalosporins.
Indication
Pharyngitis/Tonsillitis, acute bacterial otitis media, acute bacterial maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis, uncomplicated skin and skin-structure infections, uncomplicated urinary tract infections, uncomplicated gonorrhea, early lyme disease, impetigo.
Dosage & Administration
Adrox CV Tablet
|
Adults (13 years & older) |
||
|
Infections |
Dosage |
Duration (Days) |
| Pharyngitis/Tonsillitis | 250 mg twice daily |
5-10 |
| Acute bacterial maxillary sinusitis | 250 mg twice daily |
10 |
| Acute bacterial exacerbation of chronic bronchitis | 250-500 mg twice daily |
10 |
| Secondary bacterial infections of acute bronchitis | 250-500 mg twice daily |
5-10 |
| Uncomplicated skin and skin structure infections | 250-500 mg twice daily |
10 |
| Community acquired pneumonia | 250-500 mg twice daily |
5-10 |
| MDR typhoid fever | 500 mg twice daily |
10-14 |
| Uncomplicated urinary tract infections | 250 mg twice daily |
7-10 |
| Uncomplicated gonorrhea | 1000 mg |
Single dose |
| Lyme disease | 500 mg twice daily |
20 |
Paediatric Patients (3 months to 12 years):
Who can swallow tablets whole
|
Infection |
Dosage |
Duration (Days) |
| Acute bacterial otitis media | 250 mg twice daily |
10 |
| Acute bacterial maxillary sinusitis | 250 mg twice daily |
10 |
Contraindication
Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporins & in patients with pseudomembranous colitis.
Precaution
As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic Acid combination may result in overgrowth of non-susceptible microorganisms.
Side Effects
Generally Cefuroxime-Clavulanic Acid is well tolerated. Major adverse reaction which may occur are diarrhea, nausea, vomiting, transient elevation in AST, ALT, LDH and eosinophilia. Other adverse events that may occur are abdominal pain, abdominal cramps, flatulence, indigestion, headache, vaginitis, rash, itching, dysuria, thirst, anorexia etc.
Use in Pregnancy & Lactation
All antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary tract and other infections. Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities and consequently caution should be exercised when it is administered to a nursing mother.
Drug Interaction
Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.
Overdose
Over-dose can cause cerebral irritation leading to convulsions. In this case, serum levels can be reduced by hemodialysis and peritoneal dialysis.
Storage
Store below 30ºC, protect from light & moisture. Keep out of the reach of children.
Packaging
Adrox CV (500 mg + 125 mg) Tablet: Each box contains 14 tablets in blister pack in pouch.
Each blister in light protected tempet evident pouch to facillitate better storage.
