Composition
Each Film coated tablet contains 1250 mg of Coral Calcium Carbonate BP equivalent to 500 mg of elemental Calcium and Colecalciferol BP (Vitamin D3) 200 IU. Fosil-D has been manufactured as an easy to swallow formulation.
Pharmacology
Fosil-D provides Calcium and Vitamin D3 where Calcium Carbonate is sourced from coral origin. The Calcium Carbonate from Coral has a chemical structure that is very similar to the composition of human bone. Coral Calcium is similar to other sources but ensures better absorption.
Vitamin D3 aids in the absorption of Calcium from GI tract and helps to maintain Calcium balance in the body.
Indication
Fosil-D is indicated for the treatment and prevention of osteoporosis, osteomalacia, tetany, hypoparathyroidism, disorders of osteogenesis. Also used as supplement in case of inadequate intake of Calcium in childhood diet, rickets, pregnancy and lactation, elderly patients. Other indications include pancreatitis, phosphate binder in chronic renal failure etc.
Dosage and Administration
One tablet once or twice daily with plenty of water or as directed by the physician. Taking in full stomach ensures better absorption.
Contraindication
Hypersensitivity to any of the components, hypocalcaemia resulting from overdose of Vitamin D3, hyperparathyroidism, bone metastases, severe renal insufficiency, severe hypercalciuria, renal calculi etc.
Precautions
In presence of mild hypercalciuria, careful monitoring with reduction of dose may be needed. Plasma and serum calcium level should be monitored in mild to moderate renal impairment and also in case of long term use. Patients with renal stone or with such previous history should also take precaution.
Side Effects
Flatulence, diarrhoea, constipation, upper GI discomfort etc are rare manifestation. Hypercalcaemia due to prolong use has rarely been reported.
Drug Interaction
Oral Calcium can reduce the absorption of tetracycline & fluoride preparations and minimum 3 hours time should be allowed between ingestion of these medications. Thiazide diuretics reduces the renal excretion of Calcium. Phenytoin, barbiturates, glucocorticoids may induce metabolism of Vitamin D3. Concomitant ingestion of certain foods like spinach, cereals, milk and its derivatives may reduce the intestinal uptake of Calcium.
Use in Pregnancy and Lactation
Fosil-D can be given to pregnant and lactating mothers as per recommendation of physician.
Overdose
At high doses it may result in nausea, vomiting, dizziness, anorexia, abdominal cramps, headache, constipation, irritability etc. Treatment includes cessation of therapy and adequate rehydration.
Storage
Store below 30°C, protect from light & moisture. Keep out of the reach of children.
Packing
Each box contains 30 tablets in Alu-Alu blister pack.
