Combomin Tablet

Thiamine 100 mg (vit-B1)+ Pyridoxine 200 mg(vit-B6)+Cyanocobalamin 200 mcg (vit-B12)

COMPOSITION

Combomin Tablet: Each film-coated tablet contains Thiamine Mononitrate (Vitamin B1) BP 100 mg, Pyridoxine Hydrochloride (Vitamin B6) BP 200 mg, Cyanocobalamin (Vitamin B12) BP 200 mcg.

PHARMACOLOGY

Combomin is a combination of Thiamine Mononitrate (Vitamin B1), Pyridoxine Hydrochloride (Vitamin B6) & Cyanocobalamin (Vitamin B12).These vitamins play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism. This combination supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism and the natural repair mechanism. The combination of these three vitamins shows better efficacy than that of the individual vitamin.

INDICATION

Combomin is indicated where a deficiency of the relevant vitamins exists. It is indicated in the treatment of polyneuropathy of any origin such as diabetic, alcoholic or toxic neuropathies, neuritis, cervical syndrome, shoulder-arm syndrome, sciatica, peripheral neuralgia, facial neuralgia, lumbago, intercostal neuralgia, myalgia, spinal pain and Herpes Zoster.

DOSE AND ADMINISTRATION

1 to 3 tablets daily or as directed by the physician.

CONTRAINDICATION

It should not be used in the patients on Levodopa therapy and hypersensitivity to any ingredient of the product.

SIDE EFFECTS

Generally well tolerated. In rare cases few allergic responses may be seen.

WARNING & PRECAUTION 

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of Cyanocobalamin.

USE IN PREGNANCY AND LACTATION

Combomin is safe for pregnant woman. It is not known whether thiamine (Vitamin B1) is excreted in breast milk or not, but may be taken cautiously during lactation. Vitamin B6 & Vitamin B12 have no adverse effect during lactation.

DRUG INTERACTION

Pyridoxine Hydrochloride (Vitamin B6) reduces therapeutic effect of Levodopa but it does not occur if a dopa decarboxylase inhibitor is also given. Neomycin, Chloramphenicol, Aminosalisylic acid & H2 receptor antagonist may reduce Vitamin B12 absorption.

STORAGE

Protect from light and moisture. Store in a dry place below 300C. Keep out of the reach of Children.

PACKING

Combomin Tablet: Each box containing 10 x3’s tablets in blister pack

Combomin Tablet
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