Each film-coated tablet contains Thiamine Mononitrate (Vitamin B1) BP 100 mg, Pyridoxine Hydrochloride (Vitamin B6) BP 200 mg, Cyanocobalamin (Vitamin B12) BP 200 mcg.
Combomin is a combination of Thiamine Mononitrate (Vitamin B1), Pyridoxine Hydrochloride (Vitamin B6) & Cyanocobalamin (Vitamin B12). These vitamins play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism. This combination supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism and the natural repair mechanism. The combination of these three vitamins shows better efficacy than that of the individual vitamin.
Combomin is indicated where a deficiency of the relevant vitamins exists. It is indicated in the treatment of polyneuropathy of any origin such as diabetic, alcoholic or toxic neuropathies, neuritis, cervical syndrome, shoulder-arm syndrome, sciatica, peripheral neuralgia, facial neuralgia, lumbago, intercostal neuralgia, myalgia, spinal pain and Herpes Zoster.
Dosage and Administration
1 to 3 tablets daily or as directed by the physician.
It should not be used in the patients on Levodopa therapy and hypersensitivity to any ingredient of the product.
Generally well tolerated. In rare cases few allergic responses may be seen.
Warning & Precaution
Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of vitamin B for the treatment of optic neuropathies associated with raised plasma concentrations of Cyanocobalamin.
Use in Pregnancy and Lactation
Combomin is safe for pregnant woman. It is not known whether Thiamine (Vitamin B1) is excreted in breast milk or not, but may be taken cautiously during lactation. Vitamin B6 & Vitamin B12 have no adverse effect during lactation.
Pyridoxine Hydrochloride (Vitamin B6) reduces therapeutic effect of Levodopa but it does not occur if a dopa decarboxylase inhibitor is also given. Neomycin, Chloramphenicol, Aminosalisylic acid & H2 receptor antagonist may reduce Vitamin B12 absorption.
No overdose symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic and supportive.
Store in a cool & dry place below 30ºC. Protect from light and moisture. Keep out of reach of children.
Each box containing 30’s tablets in blister pack.