Metodex Syrup

Metodex Syrup
Dextromethorphan 10mg / 5 ml

Each 5 ml syrup contains 10 mg Dextromethorphan Hydrobromide BP.

Metodex (Dextromethorphan) suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Metodex (Dextromethorphan) shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives and is also used to study the involvement of glutamate receptors in neurotoxicity.

Metodex (Dextromethorphan) is indicated in Chronic dry cough or unproductive cough; Acute dry cough which is interfering with normal function or sleep.

Dosage & Administration

  • Adults and Children over 12 years: 15 to 30 mg three to four times per day. However, 60 mg doses up to four times per day have been used without increased side effects.
  • Children between 6 and 12 years: 5-15 mg up to four times per day.
  • Children between 2 and 6 years: 5-5 mg up to four times per day.

Hypersensitivity to Dextromethorphan or any other component.

Precautions & Warnings
Do not use Metodex (Dextromethorphan) to control a cough that is associated with smoking, asthma, or emphysema, or a cough that is productive (produces sputum or phlegm).

Side Effects
Adverse effects with Metodex (Dextromethorphan) are rare, but nausea and dizziness sometimes occur. The drug produces no analgesia or addiction and little or no CNS depression. Excitation, confusion and respiratory depression may occur after overdosage.

Pregnancy & Lactation
Pregnancy: Adequate and well-controlled studies in human have not been done. However, Metodex (Dextromethorphan) has not been reported to cause birth defects.

Lactation: It is not known whether Metodex (Dextromethorphan) passes into breast milk. However, Metodex (Dextromethorphan) has not been reported to cause problems in nursing babies.

The following medicines should be taken carefully while concomitantly use with Metodex (Dextromethorphan): Amiodarone, Fluoxetine, Quinidine, CNS depressants and Monoamine oxidase (MAO) inhibitors.

Overdose Effects
Symptoms: In mild overdose, tachycardia,

hypertension, vomiting, mydriasis, diaphoresis, nystagmus, euphoria, loss of motor coordination, and giggling: in moderate intoxication, in addition to those listed above, hallucinations and a plodding ataxic gait; in severely intoxication, agitation or somnolence.

Management: treatment is symptomatic and supportive. Naloxone may be useful in reversing toxicity.

Store below 30°C, protect from light and moisture. Keep out of reach of children.

Each PET bottle contains 100 ml syrup and a measuring cup.

Metodex Syrup
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