COMPOSITION
Mucovan Syrup: Each 5 ml of syrup contains Ambroxol Hydrochloride BP 15 mg.
PHARMACOLOGY
Mucovan (Ambroxol) is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism leading to liquefaction of mucus in the lumen of respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Mucovan (Ambroxol) has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.
INDICATION
Mucovan (Ambroxol) is used in the treatment of Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis & Chronic pneumonia etc.
DOSE AND ADMINISTRATION
Average daily dose (preferably after meal)
2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
10 years and adults: 10 ml (2 teaspoonful) 3 times a day.
CONTRAINDICATION
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.
WARNING AND PRECAUTION
Mucovan (Ambroxol) should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution
SIDE EFFECTS
Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema has been reported.
USE IN PREGNANCY AND LACTATION
Teratogenic and foetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during theist trimester. Safety during lactation has not been established yet.
DRUG INTERACTION
Mucovan (Ambroxol) should not be taken simultaneously with antitussives (e.g. Codeine) because phlegm, which has been liquefied by Ambroxol might not be expectorated.
STORAGE
Store in a cool & dry place below 30º C. Protect from light and moisture. Keep out of reach of children.
PACKING
Mucovan Syrup: Bottle contains 100 ml syrup and a measuring cup.
