Palmitizer Hand Rub contains 0.5% w/v Chlorhexidine Gluconate (equivalent to 2.5% v/v Chlorhexidine Gluconate solution BP) in 70% v/v Isopropyl Alcohol BP.
Chlorhexidine is a very potent cationic chemoprophylactic agent that has a broad-spectrum of activity against gm+ve and gm-ve bacteria. It is both bacteriostatic and bactericidal depending on its concentration. The bactericidal effect, which is achieved at high concentrations, is due to the binding of the cationic to negatively charged bacterial cell walls and extramicrobial complexes. Bacteriostatic effect is achieved at low concentrations which causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.
Isopropyl Alcohol is an isomer of propyl alcohol with antibacterial properties. Although the exact mechanism of isopropanol’s disinfecting action is not known, it might kill cells by denaturing cell proteins and DNA, interfering with cellular metabolism, and dissolving cell lipo-protein membranes. Isopropanol is used in soaps and lotions as an antiseptic. 70 % isopropyl alcohol solution kills microorganisms by dissolving plasma membrane of the cell wall.
For the disinfection of clean and intact skin. For pre-operative surgical hand disinfection, hand disinfection on the ward prior to aseptic procedures or after handling contaminated materials. For disinfection of the patients’ skin prior to surgery or other invasive procedures
DOSAGE AND ADMINISTRATION
Pre-operative surgical hand disinfection: Dispense 5 ml of solution and spread thoroughly over both hands and forearms, rubbing vigorously. When dry apply a further 5 ml and repeat the procedure.
Antiseptic hand disinfection on the ward: Dispense 3-5 ml of solution and spread thoroughly over the hands and wrists rubbing vigorously until dry.
Disinfection of patients skin: Prior to surgery apply the solution to a sterile swab and rub vigorously over the operation site for a minimum of 2 minutes. Chlorhexidine Gluconate is also used for preparation of the skin prior to invasive procedures such as venepuncture.
Palmitizer Hand Rub is contraindicated for persons who have previously shown a hypersensitivity reaction to this medication or to any of its ingredients.However, such reactions are extremely rare.
WARNING AND PRECAUTION
- Highly Flammable. Keep away from fire or flame
- For external use only
- Avoid contact with brain, meninges, middle ear or sensitive tissues and eyes. In case of contact with eye, flush with water
- Discontinue use if skin irritation occurs
- Keep out of reach of children
Irritative skin reactions can occasionally occur. Generalized allergic reactions have also been reported but are extremely rare.
USE IN PREGNANCY AND LACTATION
No untoward effects are known
Palmitizer is incompatible with soaps and other anionic agents. Hypochlorite bleaches may cause brown stains to develop in fabrics which have previously been in contact with chlorhexidine solutions.
Palmitizer Hand Rub should be stored in a tightly closed container in a cool & dry place, protected from light, well-ventilated area. Due to the chemical’s extreme flammability, it must be kept away from all possible ignition sources, including heat, sparks, and flames. Keep out of reach of children.
Palmitizer Hand Rub pen device: Bottle containing 10 ml .